Voice Bandwidth Saving System

Cheri Perceptions introduces the Voice Bandwith Saving System (VBSS). It acts independently of any proprietary system, and can potentially half the amount of data for a single transfer. This performance increases as the number of users grows. In addition, it ensures quality of service without sacrificing security. We, at Cheri Perception, will aim our product at small businesses, and as the VoIP market matures, we perceive larger companies, or even telephone service providers, becoming our potential customer

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

Pulse designs on TR-MAS UWB

Ultra Wideband (UWB) communication is considered to be a leading technology to enable high data throughput with low cost and low power consumption over a short-range distance. Its applications include high precision radar, consumer electric devices, and wireless sensor networks. Various design methods of UWB system schemes and pulse shapes have been proposed. The Time Hopped (TH) Transmitted Reference scheme with multiple autocorrelation sampling detection (TR-MAS) enables the receiver to obtain and capture the received signals autocorrelation side lobe energy while increasing multi-user capacity. This research proposes the application of modern pulse designs that meet the FCC requirements to the TR-MAS system, and compares the BER performance of the pulses on the TR-MAS UWB communication system in a multi-access environment

Polychlorinated biphenyls impair dibutyryl cAMP-induced astrocytic differentiation in rat C6 glial cell line

In the central nervous system, alteration of glial cell differentiation can affect brain functions. Polychlorinated biphenyls (PCBs) are persistent environmental chemical contaminants that exert neurotoxic effects in glial and neuronal cells. We examined the effects of a commercial mixture of PCBs, Aroclor1254 (A1254) on astrocytic differentiation of glial cells, using the rat C6 cell line as in vitro model. The exposure for 24 h to sub-toxic concentrations of A1254 (3 or 9 μM) impaired dibutyryl cAMP-induced astrocytic differentiation as showed by the decrease of glial fibrillary acidic protein (GFAP) protein levels and inhibition in change of cell morphology toward an astrocytic phenotype. The A1254 inhibition was restored by the addition of a protein kinase C (PKC) inhibitor, bisindolylmaleimide (bis), therefore indicating that PCBs disturbed the cAMP-induced astrocytic differentiation of C6 cells via the PKC pathway. The phosphorylation of signal transducer and activator of transcription 3 (STAT3) is essential for cAMP-induced transcription of GFAP promoter in C6 cells. Our results indicated that the exposure to A1254 (3 or 9 μM) for 24 h suppressed cAMP-induced STAT3 phosphorylation. Moreover, A1254 reduced cAMP-dependent phosphorylation of STAT3 requires inhibition of PKC activity. Together, our results suggest that PCBs induce perturbation in cAMP/PKA and PKC signaling pathway during astrocytic differentiation of glial cells